Neuronal cell membranes become rigid with aging.
نویسندگان
چکیده
منابع مشابه
Increased fragility of neuronal membranes with aging.
Changes in membrane integrity have been implicated as a contributing factor in the aging process. We have examined the relative stability of synaptosomal membranes from young and aged mice, in response to chemically induced damage. The basal characteristics of the resting synaptosomes prepared from mice of either age were indistinguishable, as judged by intracellular levels of ionic calcium and...
متن کاملRigid chiral membranes.
Statistical ensembles of flexible two-dimensional fluid membranes arise naturally in the description of many physical systems. Typically one encounters such systems in a regime of low tension but high stiffness against bending, which is just the opposite of the regime described by the Polyakov string. We study a class of couplings between membrane shape and in-plane order which break 3-space pa...
متن کاملRigid proteins and softening of biological membranes-with application to HIV-induced cell membrane softening.
A key step in the HIV-infection process is the fusion of the virion membrane with the target cell membrane and the concomitant transfer of the viral RNA. Experimental evidence suggests that the fusion is preceded by considerable elastic softening of the cell membranes due to the insertion of fusion peptide in the membrane. What are the mechanisms underpinning the elastic softening of the membra...
متن کاملDynamic phase separation of fluid membranes with rigid inclusions.
Membrane shape fluctuations induce attractive interactions between rigid inclusions. Previous analytical studies showed that the fluctuation-induced pair interactions are rather small compared to thermal energies, but also that multibody interactions cannot be neglected. In this paper, it is shown numerically that shape fluctuations indeed lead to the dynamic separation of the membrane into pha...
متن کاملNeuronal dysfunction with aging and its amelioration
The author focused on the functional decline of synapses in the brain with aging to understand the underlying mechanisms and to ameliorate the deficits. The first attempt was to unravel the neuronal functions of gangliosides so that gangliosides could be used for enhancing synaptic activity. The second attempt was to elicit the neuronal plasticity in aged animals through enriched environmental ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Seibutsu Butsuri
سال: 1989
ISSN: 0582-4052,1347-4219
DOI: 10.2142/biophys.29.4_191